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Methyl-Guard Plus

Methyl-Guard Plus

Regular price $57.00 USD
Regular price Sale price $57.00 USD
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Various conditions and stressors can have an adverse impact on the body’s methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. In addition, approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally.


Thorne’s Methyl-Guard Plus features betaine (trimethylgycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), as well as the active forms of vitamins B2 and B6, for providing efficient nutritional support for the body’s methylation challenges.*


Benefits of Thorne’s Methyl-Guard Plus:

  • Nutritional support for individuals who have MTHFR gene mutations*
  • Enhanced cellular energy production fights fatigue*
  • Helps maintain a healthy homocysteine level in the blood, which supports cardiovascular, cognitive, and bone health*
  • Promotes fat metabolism and lean body composition*
  • Supports neurotransmitter production – natural chemicals that play an important role in nervous system functions, like attention, focus, mood, and sleep*
  • Promotes liver detoxification of many substances, including hormones like estrogen*


Why is methylation important:

Methylation is a simple reaction where a small molecule known as a “methyl group” is transferred from one substance to another. Methylation significantly impacts many biochemical reactions in the body and plays a beneficial role in:

  • Cardiovascular health
  • Cellular energy production
  • Fat metabolism
  • Neurological function
  • DNA production
  • Liver detoxification processes
  • Eye health
  • Histamine balance


Who can benefit from Methyl-Guard Plus:

  • Individuals with mutations to MTHFR and other genes that adversely affect methylation*
  • Aging individuals wanting to support their cardiovascular, cognitive, and metabolic health*
  • Women seeking support for estrogen metabolism and bone health*
  • Individuals wanting nutritional support for fat metabolism and maintenance of a healthy body composition*
  • Anyone with limited consumption of methylation-supportive foods like green leafy vegetables, legumes, and cruciferous vegetables


Features of Methyl-Guard Plus:

  • Betaine, also known as trimethylglycine, is a superior methyl donor 
  • The methylated forms of vitamin B12 (methylcobalamin) and folate (5-MTHF) benefit individuals with certain gene mutations*
  • Active forms of vitamins B2 and B6 – key cofactors in methylation processes
  • B vitamins in their active, tissue-ready forms means your body gets the greatest benefit with the least additional work*
  • Robust methylation support in fewer capsules per day than Thorne’s original Methyl-Guard®

Suggested Use:

Take 1-3 capsules daily or as recommended by your health professional.



This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.


If pregnant, consult your health professional before using this product.


5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

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